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1.

CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity.

Hammerschmidt, Philipp; Ostkotte, Daniela; Nolte, Hendrik; Gerl, Mathias J; Jais, Alexander; Brunner, Hanna L; Sprenger, Hans-Georg; Awazawa, Motoharu; Nicholls, Hayley T; Turpin-Nolan, Sarah M; Langer, Thomas; Krüger, Marcus; Brügger, Britta; Brüning, Jens C.

Cell; 177(6): 1536-1552.e23, 2019 05 30.

Artículo en Inglés | MEDLINE | ID: mdl-31150623

2.

Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation.

Brandt, Claus; Nolte, Hendrik; Henschke, Sinika; Engström Ruud, Linda; Awazawa, Motoharu; Morgan, Donald A; Gabel, Paula; Sprenger, Hans-Georg; Hess, Martin E; Günther, Stefan; Langer, Thomas; Rahmouni, Kamal; Fenselau, Henning; Krüger, Marcus; Brüning, Jens C.

Cell; 175(5): 1321-1335.e20, 2018 11 15.

Artículo en Inglés | MEDLINE | ID: mdl-30445039

3.

Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition.

Fulzele, Keertik; Riddle, Ryan C; DiGirolamo, Douglas J; Cao, Xuemei; Wan, Chao; Chen, Dongquan; Faugere, Marie-Claude; Aja, Susan; Hussain, Mehboob A; Brüning, Jens C; Clemens, Thomas L.

Cell; 185(4): 746, 2022 Feb 17.

Artículo en Inglés | MEDLINE | ID: mdl-35180388

4.

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity.

Jais, Alexander; Solas, Maite; Backes, Heiko; Chaurasia, Bhagirath; Kleinridders, André; Theurich, Sebastian; Mauer, Jan; Steculorum, Sophie M; Hampel, Brigitte; Goldau, Julia; Alber, Jens; Förster, Carola Y; Eming, Sabine A; Schwaninger, Markus; Ferrara, Napoleone; Karsenty, Gerard; Brüning, Jens C.

Cell; 165(4): 882-95, 2016 May 05.

Artículo en Inglés | MEDLINE | ID: mdl-27133169

5.

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue.

Steculorum, Sophie M; Ruud, Johan; Karakasilioti, Ismene; Backes, Heiko; Engström Ruud, Linda; Timper, Katharina; Hess, Martin E; Tsaousidou, Eva; Mauer, Jan; Vogt, Merly C; Paeger, Lars; Bremser, Stephan; Klein, Andreas C; Morgan, Donald A; Frommolt, Peter; Brinkkötter, Paul T; Hammerschmidt, Philipp; Benzing, Thomas; Rahmouni, Kamal; Wunderlich, F Thomas; Kloppenburg, Peter; Brüning, Jens C.

Cell; 165(1): 125-138, 2016 Mar 24.

Artículo en Inglés | MEDLINE | ID: mdl-27015310

6.

Hypothalamic UDP Increases in Obesity and Promotes Feeding via P2Y6-Dependent Activation of AgRP Neurons.

Steculorum, Sophie M; Paeger, Lars; Bremser, Stephan; Evers, Nadine; Hinze, Yvonne; Idzko, Marco; Kloppenburg, Peter; Brüning, Jens C.

Cell; 162(6): 1404-17, 2015 Sep 10.

Artículo en Inglés | MEDLINE | ID: mdl-26359991

7.

Die another day: a painless path to longevity.

Steculorum, Sophie M; Brüning, Jens C.

Cell; 157(5): 1004-6, 2014 May 22.

Artículo en Inglés | MEDLINE | ID: mdl-24855937

8.

Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding.

Vogt, Merly C; Paeger, Lars; Hess, Simon; Steculorum, Sophie M; Awazawa, Motoharu; Hampel, Brigitte; Neupert, Susanne; Nicholls, Hayley T; Mauer, Jan; Hausen, A Christine; Predel, Reinhard; Kloppenburg, Peter; Horvath, Tamas L; Brüning, Jens C.

Cell; 156(3): 495-509, 2014 Jan 30.

Artículo en Inglés | MEDLINE | ID: mdl-24462248

9.

NK cells link obesity-induced adipose stress to inflammation and insulin resistance.

Wensveen, Felix M; Jelencic, Vedrana; Valentic, Sonja; Sestan, Marko; Wensveen, Tamara Turk; Theurich, Sebastian; Glasner, Ariella; Mendrila, Davor; Stimac, Davor; Wunderlich, F Thomas; Brüning, Jens C; Mandelboim, Ofer; Polic, Bojan.

Nat Immunol; 16(4): 376-85, 2015 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-25729921

10.

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin.

Mauer, Jan; Chaurasia, Bhagirath; Goldau, Julia; Vogt, Merly C; Ruud, Johan; Nguyen, Khoa D; Theurich, Sebastian; Hausen, A Christine; Schmitz, Joel; Brönneke, Hella S; Estevez, Emma; Allen, Tamara L; Mesaros, Andrea; Partridge, Linda; Febbraio, Mark A; Chawla, Ajay; Wunderlich, F Thomas; Brüning, Jens C.

Nat Immunol; 15(5): 423-30, 2014 May.

Artículo en Inglés | MEDLINE | ID: mdl-24681566

11.

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity.

Jais, Alexander; Solas, Maite; Backes, Heiko; Chaurasia, Bhagirath; Kleinridders, André; Theurich, Sebastian; Mauer, Jan; Steculorum, Sophie M; Hampel, Brigitte; Goldau, Julia; Alber, Jens; Förster, Carola Y; Eming, Sabine A; Schwaninger, Markus; Ferrara, Napoleone; Karsenty, Gerard; Brüning, Jens C.

Cell; 166(5): 1338-1340, 2016 Aug 25.

Artículo en Inglés | MEDLINE | ID: mdl-27565353

12.

N⁶-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.

Zhou, Jun; Wan, Ji; Shu, Xin Erica; Mao, Yuanhui; Liu, Xiao-Min; Yuan, Xin; Zhang, Xingqian; Hess, Martin E; Brüning, Jens C; Qian, Shu-Bing.

Mol Cell; 69(4): 636-647.e7, 2018 02 15.

Artículo en Inglés | MEDLINE | ID: mdl-29429926

13.

Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition.

Fulzele, Keertik; Riddle, Ryan C; DiGirolamo, Douglas J; Cao, Xuemei; Wan, Chao; Chen, Dongquan; Faugere, Marie-Claude; Aja, Susan; Hussain, Mehboob A; Brüning, Jens C; Clemens, Thomas L.

Cell; 142(2): 309-19, 2010 Jul 23.

Artículo en Inglés | MEDLINE | ID: mdl-20655471

14.

Lipid signalling drives proteolytic rewiring of mitochondria by YME1L.

MacVicar, Thomas; Ohba, Yohsuke; Nolte, Hendrik; Mayer, Fiona Carola; Tatsuta, Takashi; Sprenger, Hans-Georg; Lindner, Barbara; Zhao, Yue; Li, Jiahui; Bruns, Christiane; Krüger, Marcus; Habich, Markus; Riemer, Jan; Schwarzer, Robin; Pasparakis, Manolis; Henschke, Sinika; Brüning, Jens C; Zamboni, Nicola; Langer, Thomas.

Nature; 575(7782): 361-365, 2019 11.

Artículo en Inglés | MEDLINE | ID: mdl-31695197

15.

Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes.

Teo, Jonathan D; Marian, Oana C; Spiteri, Alanna G; Nicholson, Madeline; Song, Huitong; Khor, Jasmine X Y; McEwen, Holly P; Ge, Anjie; Sen, Monokesh K; Piccio, Laura; Fletcher, Jessica L; King, Nicholas J C; Murray, Simon S; Brüning, Jens C; Don, Anthony S.

Glia; 71(4): 1120-1141, 2023 04.

Artículo en Inglés | MEDLINE | ID: mdl-36583573

16.

Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1.

Kohlhaas, Vivien; Blakemore, Stuart James; Al-Maarri, Mona; Nickel, Nadine; Pal, Martin; Roth, Andreas; Hövelmeyer, Nadine; Schäfer, Stephan C; Knittel, Gero; Lohneis, Philipp; Nikolic, Milos; Wiederstein, Janica L; Franitza, Marek; Georgomonolis, Theodoros; Reinart, Nina; Herling, Marco; Herling, Carmen; Hartmann, Elena M; Rosenwald, Andreas; Klapper, Wolfram; Büttner, Reinhard; Moia, Riccardo; Rossi, Davide; Boldorini, Renzo; Gaidano, Gianluca; Frenzel, Lukas P; Reinhardt, Hans Christian; Brüning, Jens C; Hallek, Michael; Krüger, Marcus; Peifer, Martin; Pallasch, Christian P; Wunderlich, F Thomas.

Blood; 137(5): 646-660, 2021 02 04.

Artículo en Inglés | MEDLINE | ID: mdl-33538798

17.

Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells.

Schenten, Dominik; Nish, Simone A; Yu, Shuang; Yan, Xiting; Lee, Heung Kyu; Brodsky, Igor; Pasman, Lesley; Yordy, Brian; Wunderlich, F Thomas; Brüning, Jens C; Zhao, Hongyu; Medzhitov, Ruslan.

Immunity; 40(1): 78-90, 2014 Jan 16.

Artículo en Inglés | MEDLINE | ID: mdl-24439266

18.

Contribution of specific ceramides to obesity-associated metabolic diseases.

Hammerschmidt, Philipp; Brüning, Jens C.

Cell Mol Life Sci; 79(8): 395, 2022 Jul 05.

Artículo en Inglés | MEDLINE | ID: mdl-35789435

19.

FOXO1 couples metabolic activity and growth state in the vascular endothelium.

Wilhelm, Kerstin; Happel, Katharina; Eelen, Guy; Schoors, Sandra; Oellerich, Mark F; Lim, Radiance; Zimmermann, Barbara; Aspalter, Irene M; Franco, Claudio A; Boettger, Thomas; Braun, Thomas; Fruttiger, Marcus; Rajewsky, Klaus; Keller, Charles; Brüning, Jens C; Gerhardt, Holger; Carmeliet, Peter; Potente, Michael.

Nature; 529(7585): 216-20, 2016 Jan 14.

Artículo en Inglés | MEDLINE | ID: mdl-26735015

20.

Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation.

Ding, Xiaolei; Willenborg, Sebastian; Bloch, Wilhelm; Wickström, Sara A; Wagle, Prerana; Brodesser, Susanne; Roers, Axel; Jais, Alexander; Brüning, Jens C; Hall, Michael N; Rüegg, Markus A; Eming, Sabine A.

J Allergy Clin Immunol; 145(1): 283-300.e8, 2020 01.

Artículo en Inglés | MEDLINE | ID: mdl-31401286

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CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity.

Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation.

Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition.

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity.

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue.

Hypothalamic UDP Increases in Obesity and Promotes Feeding via P2Y6-Dependent Activation of AgRP Neurons.

Die another day: a painless path to longevity.

Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding.

NK cells link obesity-induced adipose stress to inflammation and insulin resistance.

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin.

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity.

N⁶-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.

Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition.

Lipid signalling drives proteolytic rewiring of mitochondria by YME1L.

Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes.

Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1.

Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells.

Contribution of specific ceramides to obesity-associated metabolic diseases.

FOXO1 couples metabolic activity and growth state in the vascular endothelium.

Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation.